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. 1986 Mar;83(5):1369–1373. doi: 10.1073/pnas.83.5.1369

The genome of frog erythrocytes displays centuplicate replications.

N H Orr, M A DiBerardino, R G McKinnell
PMCID: PMC323077  PMID: 3485285

Abstract

Seven nuclear lines derived from erythrocyte nuclei of Rana pipiens were produced by serial nuclear transplantation into oocytes and eggs. Even at the termination of the experiments, embryos and tadpoles developed in the eighth transplant generations. Thus, there was no evidence that the mitotic progeny of the erythrocyte nuclei lost their ability to replicate their genomes and continue cell cycling. We conclude that the genome of noncycling and terminally differentiated erythrocytes maintains its potential for widespread replication and extensive reversal of gene function in excess of a hundred (centuplicate) cell cycles.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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