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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Peptides. 2011 Oct 12;32(12):2504–2510. doi: 10.1016/j.peptides.2011.10.007

Figure 2. Combination of analogs affect biological responses.

Figure 2

The activity of AFPep (Panel A) or of cyclo[EKTOVNOGN]FI (Panel B, indicated as N-FI) is decreased in the presence of an analog with an intact pharmacophore and a hydrophilic tail (cyclo[EKTOVNOGN]FS, indicated as N-FS) which may bind preferentially to, and activate, a putative low affinity receptor. The activity of AFPep is enhanced (Panel C), while the activity of cyclo[EKTOVNOGN]FI (indicated as N-FI) is unaffected (Panel D) in the presence of an analog with a disrupted pharmacophore and a hydrophilic tail, (namely cyclo[EKTOVGOGN]FS, indicated as G-FS) which may bind preferentially to, but not activate, the low affinity receptor.