Skip to main content
. 2011 Nov;164(6):1580–1589. doi: 10.1111/j.1476-5381.2011.01498.x

Figure 4.

Figure 4

(A) Original tracing showing the effects of adenosine (1 µM) and the A1, A2A and A3 receptor agonists, CPA (0.1 µM), CGS-21680 (5 µM) and IB-MECA (3 µM), respectively, on the neurally evoked cholinergic contraction (0.5-ms pulse, 4 Hz, submaximal voltage for 10 s) in the longitudinal muscle of mouse duodenum. (B) Histogram showing the effects induced on the neurally evoked cholinergic contraction by: (i) adenosine (1 µM) alone or in the presence of the A1, A2A and A3 receptor antagonists DPCPX (10 nM, n = 4), ZM 241385 (10 nM, n = 4) and MRS 1220 (0.1 µM, n = 3), respectively; (ii) CPA (0.1 µM) alone or in the presence of DPCPX (10 nM, n = 3); (iii) CGS-21680 (5 µM) alone or in the presence of ZM 241385 (10 nM, n = 4). Data are means ± SEM and are expressed as a percentage of the amplitude of contraction induced by CCh (10 µM). *P ≤ 0.05 when compared with the respective control.