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. 2011 Nov;164(6):1698–1710. doi: 10.1111/j.1476-5381.2011.01491.x

Figure 6.

Figure 6

Effects of picrotoxin, TTX and finasteride on the γ-CD-induced decrease in basal sEPSC frequency. (A) A typical time course of sEPSC frequency before and during the application of 500 µM γ-CD in the presence of 30 µM picrotoxin. The number of events in every 10 s period was summed and plotted. (B) A typical time course of sEPSC frequency before and during the application of 500 µM γ-CD in the presence of 300 nM TTX. The number of events in every 10 s period was summed and plotted. (C) A typical time course of sEPSC frequency before and during the application of 500 µM γ-CD in the presence of 10 µM finasteride. The number of events in every 10 s period was summed and plotted. Note that finasteride (10 µM) was added in the incubation solution immediately after making hippocampal slices. (D) Changes of the basal frequency (a) and amplitude (b) of sEPSCs by γ-CD in the absence and presence of 30 µM picrotoxin (Picro; n = 10), 300 nM TTX (n = 10) and 10 µM finasteride (Fina; n = 7).