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. 2011 Nov 15;3(11):2238–2254. doi: 10.3390/v3112238

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Representation of the genetic organization of hepatitis C virus (HCV). The N-terminal part of the genome comprises the structural elements core (C)—the forming unit of the capsid and the envelope glycoproteins, E1 and E2. The C-terminal part of the genome consists of the non-structural proteins (NS3 to NS5B) responsible for HCV genome amplification. p7 and NS2 are non-structural protein dispensable for replication, but essential for viral assembly. HCV proteins are synthesized as a polyprotein, which is processed by endogenous proteases (full circle—signal peptide peptidase, open diamond— signal peptidase) or viral encoded proteases: NS2 (full diamond) and NS3 (open circle) to generate 10 mature proteins.