Table 1.

- The effects of the Growth Factors produced by platelets.

PDGF	Macrophage activation Angiogenesis Fibroblast chemotaxis and proliferative activity Collagen synthesis Proliferation of bone cells
TGF-beta	Enhances the proliferative activity of fibroblasts Stimulates biosynthesis of type I collagen and fibronectin Induces deposition of bone matrix Inhibits osteoclast formation and bone resorption
IGF-I	Chemotactic for fibroblasts and stimulates protein synthesis Enhances bone formation by proliferation and differentiation of osteoblasts
PDAF	Induces vascularisation by stimulating vascular endothelial cells
PDEGF	Promotes wound healing by stimulating the proliferation of keratinocytes and dermal fibroblasts
PF-4	Stimulates the initial influx of neutrophils into wounds Migration and mitosis of endothelial cells
EGF	Cellular proliferation Differentiation of epithelial cells
VEGF	Migration and mitosis of endothelial cells Angiogenesis Creates blood vessel lumen and fenestrations Chemotactic for macrophages and granulocytes Vasodilation (indirectly by release of nitrous oxide)