Table 3. Iron Status of Infants With and Without IDA During the Course of Iron Therapy.
6-mo Cohort | 12-mo Cohort | |||
---|---|---|---|---|
IDA | Nonanemic | IDA | Nonanemic | |
Hemoglobin, g/L | ||||
Pretreatmenta | 95.0 ± 0.8 | 121.4 ± 0.6 | 104.1 ± 0.6 | 125.4 ± 0.6 |
After 6 mo of irona,b | 118.0 ± 1.2 | 127.1 ± 0.9 | 120.4 ± 0.9 | 129.2 ± 1.1 |
After 12 mo of iron | 122.1 ± 1.5 | 126.5 ± 1.8 | 124.4 ± 1.2a,b | 130.5 ± 1.4a,b |
Mean corpuscular volume, fL | ||||
Pretreatmenta | 66.1 ± 0.6 | 73.8 ± 0.4 | 66.9 ± 0.5 | 76.4 ± 0.4 |
After 6 mo of irona,b | 72.7 ± 0.5 | 76.6 ± 0.4 | 73.7 ± 0.5 | 78.2 ± 0.5 |
Free erythrocyte protoporphyrin, μg/dL RBC | ||||
Pretreatmenta | 185.7 ± 12.3 | 95.0 ± 3.1 | 163.4 ± 6.9 | 80.5 ± 1.7 |
After 6 mo of irona,b | 97.5 ± 3.5 | 76.6 ± 2.3 | 92.7 ± 4.1 | 69.1 ± 2.3 |
Ferritin, μg/L | ||||
Pretreatmenta | 10.9 ± 1.3 | 17.8 ± 1.9 | 6.2 ± 0.8 | 14.5 ± 1.1 |
After 6 mo of irona,b | 18.8 ± 1.8 | 25.0 ± 2.3 | 15.7 ± 1.3 | 23.7 ± 2.1 |
Values are mean ± SE. RBC indicates red blood cells.
Difference between IDA and nonanemic groups
change within group from previous time point significant at P< .05 for both cohorts. The only exception was hemoglobin after 12 months of iron, for which the difference between IDA and nonanemic groups and the within-group increase from 6 to 12 months of iron treatment were not significant in the 6-month cohort.