Table 2.
Subject characteristics by G1 risk allele status
| Characteristics | Wt (n = 104) | Heterozygous (n = 101) | Homozygous (n = 85) | P |
|---|---|---|---|---|
| Age at dialysis initiation | 61.8 ± 17.1a,b | 55.9 ± 16.7a | 49.0 ± 14.9b | 1.0 × 10−6 |
| Gender | 0.9314 | |||
| male | 51.0% (53) | 53.5% (54) | 52.9% (45) | |
| female | 49.0% (51) | 46.5% (47) | 47.1% (40) | |
| Median income | 0.6869 | |||
| tertile 3 | 26.9% (28) | 34.7% (35) | 35.3% (30) | |
| tertile 2 | 29.8% (31) | 33.7% (34) | 32.9% (28) | |
| tertile 1 | 37.5% (39) | 30.7% (31) | 31.8% (27) | |
| unknown | 5.8% (6) | 1.0% (1) | 0.0% (0) | |
| Census region | 0.7810 | |||
| northeast | 11.5% (12) | 13.9% (14) | 9.4% (8) | |
| Midwest/west | 20.2% (21) | 15.8% (16) | 17.7% (15) | |
| south | 64.4% (67) | 69.3% (70) | 72.9% (62) | |
| unknown | 3.9% (4) | 1.0% (1) | 0.0% (0) | |
| Access | 0.8344 | |||
| catheter | 57.7% (60) | 63.4% (64) | 58.8% (50) | |
| graft | 15.4% (16) | 10.9% (11) | 12.9% (11) | |
| fistula | 19.2% (20) | 20.8% (21) | 23.5% (20) | |
| unknown | 7.7% (8) | 5.0% (5) | 4.7% (4) | |
| Location of dialysis initiation | 0.4177 | |||
| inpatient | 78.9% (82) | 85.2% (86) | 84.7% (72) | |
| outpatient | 21.2% (22) | 14.9% (15) | 15.3% (13) | |
| Cause of ESRD | 0.9573 | |||
| hypertension | 73.1% (76) | 71.3% (72) | 71.8% (61) | |
| other | 26.9% (28) | 28.7% (29) | 27.1% (23) | |
| unknown | 0.0% (0) | 0.0% (0) | 1.2% (1) | |
| BMI | 25.9 ± 6.3 | 26.9 ± 7.5 | 27.6 ± 7.9 | 0.2838 |
| Systolic BP, mmHg | 146.6 ± 22.3 | 145.4 ± 23.5 | 141.3 ± 20.6 | 0.2514 |
| Diastolic BP, mmHg | 77.8 ± 12.9 | 79.3 ± 15.2 | 80.6 ± 14.7 | 0.3898 |
| Albumin, g/dl | 3.5 ± 0.6 | 3.4 ± 0.6 | 3.5 ± 0.6 | 0.6550 |
| Creatinine, mg/dl | 6.8 ± 2.8a,b | 7.7 ± 3.4a | 9.4 ± 3.8b | 1.0 × 10−6 |
| eGFR, ml/min per 1.73 m2 | 11.6 ± 6.6a,b | 10.4 ± 5.5a | 8.0 ± 3.5b | 8.1 × 10−5 |
| PTH, pg/ml | 332.2 ± 318.7 | 337.2 ± 249.7 | 444.9 ± 382.1 | 0.0585 |
| Calcium, mg/dl | 8.5 ± 0.9 | 8.4 ± 1.0 | 8.3 ± 1.0 | 0.5680 |
| Hemoglobin, g/dl | 9.9 ± 1.3 | 9.8 ± 1.4 | 10.1 ± 1.2 | 0.3316 |
Values with the same letter differ significantly from each other on the basis of post hoc tests.