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Steep concentration-dependent decreases in cellular putrescine and cadaverine levels in CHO and NRel-4 cells incubated with ibuprofen (0-50 μM). Fresh medium and ibuprofen were provided at time 0 and at 24 hr. of a 48 hr. incubation. Decreases in putrescine and cadaverine levels, with 2, 10 and 50 μM ibuprofen, were significant (P < 0.05) for both CHO and NRel-4 cells. N = 6. Mean ± SEM.
