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MLL3Δ/Δ mice are not as responsive as wild-type mice to DXR in regulating BA homeostasis. A–D, Quantitation of serum (A), hepatic (C), and intestinal (D) BA levels as well as gallbladder volume (B) of wild-type (WT) and MLL3Δ/Δ mice (n = 3–4) measured 24 h after ip injection of saline or DXR. E, BA levels in the intestine, gallbladder, and liver were combined together to assess the BA pool size.
