Fasting plasma insulin, C-peptide, GLP-1, and GIP levels in DKO mice. Male mice (n = 5–10) (7–9 wk of age) were fasted overnight and fasting plasma insulin (A), C-peptide (B), GLP-1 (C), and GIP (D) values were measured by commercial ELISA kit. Data are represented as mean ± sem. a, P < 0.05 vs. Akt2+/+/SGK3+/−; b, P < 0.05 vs. Akt2+/+/SGK3−/−; c, P < 0.05 vs. Akt2−/−/SGK3+/+.