Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Nov 3;25(12):2029–2040. doi: 10.1210/me.2011-1145

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2011 by The Endocrine Society

PMC Copyright notice

Fig. 2. — ER ligand-induced dimerizations [ERα/ERα-homodimerization (panel A); ERβ/ERβ-homodimerization (panel B); and ERα/ERβ-heterodimerization (panel C) studied in HEK293T cells cotransfected with respective combination of vectors (ERα/ERα: NFluc-ERα-LBD/ERα-LBD-CFluc; ERα/ERβ: NFluc-ERα-LBD/ERβ-LBD-CFluc; ERβ/ERβ: NFluc-ERβ-LBD/ERβ-LBD-CFluc) after exposure to several ligands including ERα-selective (MPP and PPT), ERβ-selective (DPN, THC, and Gen), and ER subtype nonselective ligands [ERα and ERβ; estrone (E1), E2, estriol (E3), OHT, and Ral]. The results showed significant level of luciferase signal induced by all ligands (P < 0.05). The subtype-specific ligands induced higher level of signals with their respective homodimerization along with the heterodimerization. DMSO, Dimethylsulfoxide.