Skip to main content
. 2011 Nov 17;52(12):8868–8877. doi: 10.1167/iovs.11-8033

Figure 3.

Figure 3.

The ptc2−/− retina is overproliferative. BrdU incorporation (2 hours) at 6 weeks revealed an increase in the number of proliferative cells in the ptc2−/− retina (C) when compared to wild-type (A) (n = 4). The total number of BrdU+ cells in the CMZ was increased by 54% in ptc2−/− mutants when compared with wild-type siblings (**P < 0.001, n = 4) (D). The percentage of BrdU+ cells in the INL (2.30-fold, *P < 0.01, n = 4) and ONL (2.62-fold, **P < 0.001, n = 4) were significantly increased in ptc2−/− mutants when compared to wild-type siblings (E). A statistically significant increase in the percentage of BrdU+ cells was also observed in the ONL of ptc2+/− mutants (B, E) (1.54-fold, *P < 0.01, n = 4) when compared to wild-type (A, E). Scale bar: 100 μm.