Fig. 7.

Interstudy comparison of reported phospholipid doses that have been associated with hypersensitivity reactions. In contrast to dogs, swine, and humans, rats do not exhibit anaphylactic responses until the doses are markedly elevated. Figures are based upon data reported by Szebeni et al. (73). The primary graph provides the lipid dose dependence of hypersensitivity reaction to phospholipids injection in humans, dogs, and pigs. Rats are not included in that comparison to allow for visualization of the differences between these three species. However, the insert is included to demonstrate the relative insensitivity of rats to the injected phospholipids