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. 2011 Oct 5;13(4):632–649. doi: 10.1208/s12248-011-9303-8

Table I.

PK of rHEPO Following IV or SC Injection (Values Fitted to a Simple One-Compartment Model)

Species Dog (IU/kg) Tmax (h) T1/2 elimination (h) %F T1/2 absorption (h)
IV SC
Dog 500 (0.5 mL/kg) 18.1 6.7 24.6 80.3 27.7
Rat 1,000 (1 mL/kg) 12 13.8 12.6 76 5.4
Mouse 50 (10 mL/kg) 7 11 17.7 73 0.8
Mouse 150 (10 mL/kg) 3 7.7 9.7 68
Mana (see note in legend) 7.1 34.6 22.8

In all cases, serum concentration was corrected for background levels of endogenous erythropoietin. Animal results are compared against published information on the PK of this compound in humans. Based upon the information provided by Bleuel et al. (7). Note that in reviewing available information in the citations used to derive human dose, it would appear that most of the modeling was based upon doses of approximately 250 IU/kg or less

aWeighted average of means from 13 publications (original data and calculations not provided)