Table IV.
Composition CX-Y a | Plateau value at 4 h (μg/106 cells), at 200 μg/ml initial extracellular concentrations | ||
---|---|---|---|
TCeq | B eq | I eq | |
Effect of surface charge | |||
C0-0 | 2.15 | 1.46 | 0.69 |
C5-0 | 4.78 | 2.47 | 2.31 |
C10-0 | 15.5 | 8.11 | 7.39 |
C20-0 | 24.4 | 12.7 | 11.7 |
C40-0 | 36.5 | 17.4 | 19.1 |
Effect of pegylation | |||
C20-0 | 24.4 | 12.7 | 11.7 |
C20-1 | 18.1 | 9.26 | 8.86 |
C20-2 | 10.6 | 5.73 | 4.87 |
C20-5 | 7.92 | 4.31 | 3.60 |
C40-0 | 36.5 | 17.4 | 19.1 |
C40-1 | 32.9 | 15.8 | 17.1 |
C40-2 | 21.7 | 10.8 | 10.8 |
C40-3.5 | 16.3 | 8.26 | 8.04 |
C40-5 | 13.7 | 6.64 | 7.04 |
C40-7 | 8.34 | 4.68 | 3.66 |
a X = mol.% DOTAP, Y = mol.% PEG