Table 1.
Albendazole arrests cell in the G2/M phase in a time and dose dependent fashion.
| % G2/M cells | |||||
|---|---|---|---|---|---|
| Time (hr) | ABZ (nM) | A2058 | A375 | H1530 | H446 |
| 0 | 0 | 10.6 | 4.7 | 4.3 | 0.9 |
| 12 | 100 | 10.0 | 13.1 | 3.0 | 5.2 |
| 12 | 500 | 29.3 | 65.2 | 38.6 | 47.7 |
| 12 | 1000 | 32.3 | 87.1 | 46.3 | 71.4 |
A2058 melanoma cells and H1530 SCLC cells were treated with ABZ concentrations ranging from 100 to 1000 nM for 12 hr, stained with propidium iodide, and analyzed for DNA content by flow cytometry. A total of 10 000 nuclei were analyzed from each sample, with the average of two replicates reported.