Table 1.
Baseline characteristics in study subjects with 6 year progression data and Hp genotype data by diabetes status
| Characteristic | Study subjects with type 1 diabetes | Control subjects without type 1 diabetes | ||||
|---|---|---|---|---|---|---|
| 6 Year CAC Progression ≥ 2.5 | 6 Year CAC Progression < 2.5 | 6 Year CAC Progression ≥ 2.5 | 6 Year CAC Progression < 2.5 | |||
| n = 178 | n = 258 | n = 150 | n = 376 | |||
| CAC present at baseline visit | 113(63) | 37(14) | * | 86(57) | 51(14) | * |
| Haptoglobin genotype 2-2 | 76(43) | 89(35) | 46(31) | 139(37) | ||
| Mean 6 year change in CAC volume | 7.4 ± 4.4 | 0.4 ± 0.8 | * | 5.8 ± 3.1 | 0.3 ± 0.7 | * |
| Female | 78(44) | 160(62) | * | 41(27) | 223(59) | * |
| Mean age (years) | 40.1 ± (8.1) | 34.0 ± 8.2) | * | 45.2 ± 7.3) | 39.0 ± 8.5 | * |
| Mean diastolic blood pressure (mmHg) | 78.0 ± 9.0 | 76.3 ± 8.4 | * | 83.2 ± 8.9 | 77.2 ± 7.6 | * |
| Mean systolic blood pressure (mmHg) | 120.2 ± 13.6 | 113.9 ± 12.1 | * | 120.4 ± 12.7 | 111.6 ± 11.1 | * |
| Mean body mass index (kg/m2) | 26.7 ± 4.3 | 25.6 ± 4.0 | * | 28.2 ± 4.8 | 25.3 ± 4.4 | * |
| Mean LDL cholesterol (mmol/l) | 2.7 ± 0.73 | 2.5 ± 0.7 | * | 3.1 ± 0.8 | 3.0 ± 0.8 | * |
| Mean HDL cholesterol (mmol/l) | 1.4 ± 0.4 | 1.5 ± 0.4 | * | 1.2 ± 0.3 | 1.4 ± 0.4 | * |
| Mean triglycerides (mmol/l) | 1.1 ± 0.01 | 1.0 ± 0.5 | * | 1.8 ± 1.2 | 1.3 ± 0.7 | * |
| Mean HbA1c (%) | 8.0 ± 1.2 | 7.8 ± 1.2 | 5.6 ± 0.4 | 5.4 ± 0.4 | * | |
| Ever smoker | 48(27) | 39(15) | * | 27(18) | 86(23) | |
* p-value less than 0.05 comparing CAC progression in individuals with type 1 diabetes and control subjects separately
Data are presented as mean ± sd or as n (%)