Table 3.
SNPs That Reached Combined p < 10-6 for Combined GWA Results for (Normalized) BMI
SNP | Chr | Position | Gene | Allele | Freq | Adolescents | Adults | Combined | R2 (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect | SE | P-value | Effect | SE | P-value | Effect | SE | P-value | |||||||
rs2275215 | 6 | 129903085 | LAMA2 | T | 0.73 | -0.046 | 0.033 | 0.170 | -0.097 | 0.019 | 4.10×10-7 | -0.085 | 0.022 | 3.76×10-7 | 0.28 |
rs10458787 | 10 | 4645565 | Intergenic | G | 0.76 | 0.118 | 0.035 | 8.10×10-4 | 0.076 | 0.02 | 1.90×10-4 | 0.086 | 0.024 | 9.61×10-7 | 0.27 |
Note: SNPs are ordered by chromosome and position. Positions are based on NCBI build 126. Allele and frequency refers to the major allele. Effect sizes and corresponding standard errors are in units of standard deviations of normalized BMI. R2 represents the percentage of phenotypic variance explained by the SNP.