Table 4.
Genome-wide association results for 61 known height-associated SNPs
| SNP | Chr | Position | Gene(s) | Allele | Freq | Adolescents | Adults | Combined | R2 (%) | P-value hetero | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect | SE | P-value | Effect | SE | P-value | Effect | SE | P-value | ||||||||
| rs11809207 | 1 | 26393727 | CATSPER4 | A | 0.23 | 0.049 | 0.038 | 0.195 | 0.060 | 0.029 | 0.039 | 0.057 | 0.031 | 0.014 | 0.11 | 0.87 |
| rs6686842 | 1 | 41303458 | SCMH1 | C | 0.56 | -0.046 | 0.030 | 0.126 | -0.005 | 0.017 | 0.770 | -0.015 | 0.020 | 0.315 | 0.01 | 0.23 |
| rs12735613 | 1 | 118685496 | SPAG17 | G | 0.76 | 0.008 | 0.033 | 0.820 | 0.056 | 0.019 | 3.60×10-3 | 0.044 | 0.022 | 9.73×10-3 | 0.07 | 0.21 |
| rs11205277 | 1 | 148159496 | Histone class 2A, MTMR11, SV2A, SF3B4 | G | 0.44 | 0.067 | 0.029 | 0.021 | 0.022 | 0.017 | 0.174 | 0.033 | 0.020 | 0.018 | 0.05 | 0.14 |
| rs678962 | 1 | 170456512 | DNM3 | G | 0.22 | 0.053 | 0.035 | 0.130 | 0.034 | 0.020 | 0.088 | 0.039 | 0.024 | 0.018 | 0.05 | 0.46 |
| rs2274432 | 1 | 182287568 | C1orf19,GLT25D2 | T | 0.37 | 0.007 | 0.030 | 0.804 | 0.061 | 0.018 | 6.86×10-4 | 0.048 | 0.021 | 2.23×10-3 | 0.11 | 0.12 |
| rs1390401 | 1 | 225864573 | ZNF678 | G | 0.18 | 0.093 | 0.037 | 0.012 | 0.011 | 0.021 | 0.620 | 0.031 | 0.025 | 0.096 | 0.03 | 0.05 |
| rs3791675 | 2 | 55964813 | EFEMP1 | C | 0.77 | 0.115 | 0.034 | 7.80×10-4 | 0.081 | 0.020 | 4.80×10-5 | 0.089 | 0.023 | 3.16×10-7 | 0.28 | 0.39 |
| rs6724465 | 2 | 219652090 | IHH | G | 0.90 | 0.114 | 0.049 | 0.020 | 0.033 | 0.029 | 0.250 | 0.053 | 0.034 | 0.033 | 0.05 | 0.15 |
| rs10935120 | 3 | 135715782 | ANAPC13, CEP63 | G | 0.67 | 0.047 | 0.031 | 0.132 | 0.000 | 0.018 | 0.999 | 0.011 | 0.021 | 0.457 | 0.01 | 0.19 |
| rs6440003 | 3 | 142576899 | ZBTB38 | G | 0.55 | -0.037 | 0.029 | 0.210 | -0.057 | 0.017 | 6.90×10-4 | -0.052 | 0.020 | 4.62×10-4 | 0.13 | 0.55 |
| rs6763931 | 3 | 142585523 | ZBTB38 | A | 0.35 | 0.048 | 0.029 | 0.091 | 0.062 | 0.016 | 1.51×10-4 | 0.059 | 0.019 | 3.13×10-5 | 0.16 | 0.76 |
| rs724016 | 3 | 142588260 | ZBTB38 | A | 0.56 | -0.053 | 0.029 | 0.067 | -0.063 | 0.017 | 1.60×10-4 | -0.061 | 0.020 | 3.93×10-5 | 0.18 | 0.77 |
| rs16896068 | 4 | 17553938 | LCORL | G | 0.84 | 0.052 | 0.040 | 0.190 | 0.094 | 0.023 | 2.90×10-5 | 0.084 | 0.027 | 2.68×10-5 | 0.19 | 0.36 |
| rs6830062 | 4 | 17626828 | LCORL | T | 0.84 | 0.051 | 0.040 | 0.203 | 0.098 | 0.022 | 9.70×10-6 | 0.087 | 0.026 | 7.64×10-6 | 0.20 | 0.30 |
| rs2011962 | 4 | 82439348 | PRKG2 | T | 0.16 | -0.060 | 0.033 | 0.070 | -0.031 | 0.019 | 0.102 | -0.038 | 0.022 | 0.018 | 0.04 | 0.39 |
| rs6854783 | 4 | 145862529 | HHIP | A | 0.59 | 0.106 | 0.030 | 3.86×10-4 | 0.051 | 0.016 | 2.05×10-3 | 0.064 | 0.019 | 9.22×10-6 | 0.20 | 0.11 |
| rs1492820 | 4 | 145869471 | HHIP | A | 0.54 | 0.090 | 0.029 | 2.20×10-3 | 0.044 | 0.017 | 7.90×10-3 | 0.055 | 0.020 | 1.64×10-4 | 0.15 | 0.17 |
| rs12198986 | 6 | 7665058 | BMP6 | A | 0.50 | 0.020 | 0.028 | 0.479 | 0.044 | 0.017 | 7.46×10-3 | 0.038 | 0.020 | 8.98×10-3 | 0.07 | 0.41 |
| rs10946808 | 6 | 26341366 | HIST1H1D | G | 0.28 | -0.078 | 0.032 | 0.016 | -0.063 | 0.019 | 6.90×10-4 | -0.067 | 0.022 | 2.73×10-5 | 0.18 | 0.60 |
| rs9358913 | 6 | 26347383 | HIST1H4F | A | 0.15 | 0.074 | 0.033 | 0.023 | 0.053 | 0.019 | 4.94×10-3 | 0.058 | 0.022 | 2.90×10-4 | 0.09 | 0.48 |
| rs4711269 | 6 | 31462798 | HLA-B | T | 0.16 | 0.022 | 0.035 | 0.523 | -0.017 | 0.020 | 0.383 | -0.007 | 0.024 | 0.556 | 0.00 | 0.47 |
| rs2844479 | 6 | 31680935 | HLA class III | T | 0.68 | -0.006 | 0.032 | 0.862 | 0.024 | 0.017 | 0.171 | 0.017 | 0.021 | 0.270 | 0.01 | 0.41 |
| rs3130050 | 6 | 31726740 | HLA class III | A | 0.84 | 0.052 | 0.040 | 0.199 | -0.062 | 0.023 | 6.83×10-3 | -0.034 | 0.027 | 0.086 | 0.03 | 0.01 |
| rs185819 | 6 | 32158045 | HLA class III | T | 0.52 | 0.022 | 0.029 | 0.439 | 0.041 | 0.016 | 0.013 | 0.036 | 0.019 | 0.013 | 0.07 | 0.53 |
| rs1776897 | 6 | 34302989 | HMGA1 | T | 0.49 | -0.068 | 0.054 | 0.203 | -0.125 | 0.029 | 1.31×10-5 | -0.111 | 0.035 | 7.37×10-6 | 0.62 | 0.44 |
| rs2814993 | 6 | 34726871 | C6orf106 | A | 0.15 | 0.054 | 0.040 | 0.182 | 0.084 | 0.023 | 3.36×10-4 | 0.077 | 0.027 | 1.69×10-4 | 0.15 | 0.52 |
| rs4713858 | 6 | 35510763 | ANKS1, TCP11, ZNF76, DEF6, SCUBE3 | G | 0.86 | 0.054 | 0.040 | 0.177 | 0.018 | 0.022 | 0.432 | 0.027 | 0.026 | 0.238 | 0.02 | 0.61 |
| rs314277 | 6 | 105514355 | LIN28B | A | 0.13 | -0.029 | 0.041 | 0.479 | 0.068 | 0.023 | 3.75×10-3 | 0.044 | 0.027 | 0.032 | 0.04 | 0.04 |
| rs4549631 | 6 | 127008001 | LOC387103 | C | 0.51 | 0.046 | 0.030 | 0.120 | 0.010 | 0.017 | 0.560 | 0.019 | 0.020 | 0.206 | 0.02 | 0.30 |
| rs4896582 | 6 | 142745570 | GPR126 | G | 0.70 | 0.084 | 0.033 | 9.70×10-3 | 0.079 | 0.018 | 1.40×10-5 | 0.080 | 0.022 | 6.77×10-7 | 0.27 | 0.89 |
| rs798544 | 7 | 2729628 | GNA12 | G | 0.72 | 0.052 | 0.032 | 0.106 | 0.054 | 0.018 | 2.85×10-3 | 0.054 | 0.021 | 8.49×10-4 | 0.12 | 0.92 |
| rs849141 | 7 | 28151616 | JAZF1 | A | 0.23 | 0.065 | 0.032 | 0.044 | 0.044 | 0.018 | 0.016 | 0.049 | 0.021 | 2.05×10-3 | 0.09 | 0.57 |
| rs2040494 | 7 | 92094841 | CDK6 | T | 0.53 | 0.095 | 0.029 | 8.60×10-4 | 0.037 | 0.017 | 0.028 | 0.051 | 0.020 | 4.43×10-4 | 0.13 | 0.08 |
| rs2282978 | 7 | 92102346 | CDK6 | C | 0.33 | 0.116 | 0.030 | 1.43×10-4 | 0.042 | 0.018 | 0.017 | 0.060 | 0.021 | 1.12×10-4 | 0.16 | 0.05 |
| rs10958476 | 8 | 57258362 | PLAG1, MOS, CHCHD7, RDHE2, RPS20, LYN, TGS1, PENK | C | 0.23 | 0.037 | 0.035 | 0.291 | 0.048 | 0.020 | 0.016 | 0.045 | 0.024 | 7.18×10-3 | 0.07 | 0.90 |
| rs9650315 | 8 | 57318152 | CHCHD7, RDHE2 | G | 0.87 | 0.066 | 0.044 | 0.136 | 0.074 | 0.025 | 3.00×10-3 | 0.072 | 0.030 | 1.12×10-3 | 0.12 | 0.87 |
| rs7846385 | 8 | 78322734 | PXMP3, ZFHX4 | C | 0.27 | 0.002 | 0.032 | 0.945 | 0.008 | 0.018 | 0.677 | 0.007 | 0.021 | 0.648 | 0.00 | 0.96 |
| rs10512248 | 9 | 97299524 | PTCH1 | T | 0.69 | -0.105 | 0.031 | 7.70×10-4 | -0.053 | 0.018 | 3.20×10-3 | -0.066 | 0.021 | 3.10×10-5 | 0.18 | 0.15 |
| rs4743034 | 9 | 108672174 | ZNF462 | A | 0.23 | 0.071 | 0.035 | 0.040 | 0.011 | 0.020 | 0.568 | 0.026 | 0.024 | 0.165 | 0.02 | 0.20 |
| rs7466269 | 9 | 132453905 | FUBP3 | A | 0.65 | 0.037 | 0.030 | 0.228 | 0.045 | 0.017 | 9.11×10-3 | 0.043 | 0.020 | 4.20×10-3 | 0.08 | 0.82 |
| rs1042725 | 12 | 64644614 | HMGA2 | C | 0.51 | 0.039 | 0.029 | 0.190 | 0.076 | 0.017 | 5.80×10-6 | 0.067 | 0.020 | 6.84×10-6 | 0.22 | 0.27 |
| rs11107116 | 12 | 92502635 | SOCS2 | T | 0.23 | 0.045 | 0.035 | 0.198 | 0.121 | 0.052 | 0.020 | 0.102 | 0.048 | 8.74×10-3 | 0.37 | 0.22 |
| rs3116602 | 13 | 50009356 | DLEU7 | T | 0.79 | -0.034 | 0.036 | 0.350 | 0.054 | 0.020 | 7.10×10-3 | 0.033 | 0.024 | 0.068 | 0.04 | 0.03 |
| rs3118914 | 13 | 50014902 | DLEU7 | A | 0.39 | -0.043 | 0.036 | 0.231 | 0.060 | 0.020 | 2.46×10-3 | 0.035 | 0.024 | 0.032 | 0.06 | 0.02 |
| rs7153027 | 14 | 91496975 | TRIP11, FBLN5, ATXN3, CPSF2 | A | 0.52 | 0.015 | 0.030 | 0.610 | 0.052 | 0.017 | 1.82×10-3 | 0.043 | 0.020 | 3.11×10-3 | 0.09 | 0.30 |
| rs8007661 | 14 | 91529711 | FBLN, TRIP11, ATXN3 | C | 0.54 | 0.019 | 0.029 | 0.514 | 0.001 | 0.046 | 0.976 | 0.005 | 0.042 | 0.728 | 0.00 | 0.74 |
| rs2562784 | 15 | 82077496 | SH3GL3, ADAMTSL3 | T | 0.79 | -0.091 | 0.035 | 9.98×10-3 | -0.034 | 0.054 | 0.538 | -0.048 | 0.049 | 0.071 | 0.08 | 0.38 |
| rs10906982 | 15 | 82359162 | SH3GL3, ADAMTSL3 | A | 0.52 | 0.123 | 0.029 | 1.60×10-5 | 0.057 | 0.017 | 6.90×10-4 | 0.073 | 0.020 | 5.31×10-7 | 0.27 | 0.05 |
| rs8041863 | 15 | 87160693 | ACAN | T | 0.53 | -0.038 | 0.029 | 0.190 | -0.038 | 0.017 | 0.022 | -0.038 | 0.020 | 9.51×10-3 | 0.07 | 1.00 |
| rs4533267 | 15 | 98603794 | ADAMTS17 | A | 0.28 | 0.061 | 0.033 | 0.061 | 0.045 | 0.018 | 0.015 | 0.049 | 0.022 | 1.88×10-3 | 0.10 | 0.56 |
| rs3760318 | 17 | 26271841 | CRLF3, ATAD5, CENTA2, RNF135 | C | 0.63 | 0.090 | 0.030 | 2.44×10-3 | 0.048 | 0.017 | 4.09×10-3 | 0.058 | 0.020 | 5.54×10-5 | 0.16 | 0.18 |
| rs4794665 | 17 | 52205328 | NOG, DGKE, TRIM25, COIL, RISK | A | 0.48 | 0.055 | 0.029 | 0.059 | 0.064 | 0.016 | 8.79×10-5 | 0.062 | 0.019 | 1.80×10-5 | 0.19 | 0.74 |
| rs757608 | 17 | 56852059 | BCAS3, NACA2, TBX2, TBX4 | T | 0.35 | 0.036 | 0.030 | 0.234 | 0.062 | 0.018 | 5.13×10-4 | 0.056 | 0.021 | 2.97×10-4 | 0.14 | 0.49 |
| rs4800148 | 18 | 18978326 | CABLES1, RBBP8, C18orf45 | A | 0.79 | 0.105 | 0.035 | 2.45×10-3 | 0.023 | 0.020 | 0.242 | 0.043 | 0.024 | 0.014 | 0.06 | 0.05 |
| rs8099594 | 18 | 45245158 | DYM | A | 0.66 | -0.013 | 0.031 | 0.680 | 0.043 | 0.018 | 0.015 | 0.029 | 0.021 | 0.061 | 0.04 | 0.12 |
| rs12986413 | 19 | 2121954 | DOT1L | A | 0.55 | -0.030 | 0.029 | 0.310 | -0.043 | 0.017 | 0.010 | -0.040 | 0.020 | 7.40×10-3 | 0.08 | 0.70 |
| rs967417 | 20 | 6568893 | BMP2 | C | 0.53 | 0.012 | 0.029 | 0.676 | 0.032 | 0.017 | 0.056 | 0.027 | 0.020 | 0.063 | 0.04 | 0.55 |
| rs6060369 | 20 | 33370575 | BFZB | T | 0.56 | -0.069 | 0.030 | 0.020 | -0.047 | 0.017 | 6.40×10-3 | -0.052 | 0.020 | 5.29×10-4 | 0.14 | 0.52 |
| rs6060373 | 20 | 33377622 | GDF5 | A | 0.38 | -0.069 | 0.030 | 0.020 | -0.047 | 0.017 | 6.40×10-3 | -0.052 | 0.020 | 5.29×10-4 | 0.13 | 0.52 |
| rs4911494 | 20 | 33435328 | UQCC | A | 0.05 | -0.061 | 0.030 | 0.039 | -0.052 | 0.017 | 1.91×10-3 | -0.054 | 0.020 | 1.50×10-4 | 0.03 | 0.66 |
Note: SNPs are based on those that reached p < 10-7 in Gudbjartsson et al. (2008); Lettre et al. (2008); Sanna et al. (2008); Soranzo et al. (2009); or Weedon et al. (2008). Positions are based on NCBI build 126. Genes, allele and frequency are those given in the original studies. SNPs in italics indicate those that were not directly genotyped as part of this study, and were imputed instead.