Table 5.
Genome-wide association results for 18 known BMI-associated SNPs
| SNP | Chr | Position | Gene(s) | Allele | Freq | Adolescents | Adults | Combined | R2 (%) | P-value hetero | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect | SE | P-value | Effect | SE | P-value | Effect | SE | P-value | ||||||||
| rs2568958 | 1 | 72537704 | NEGR1 | A | 0.60 | -0.029 | 0.030 | 0.337 | -0.037 | 0.017 | 0.033 | -0.035 | 0.020 | 0.023 | 0.06 | 0.82 |
| rs2815752 | 1 | 72585028 | NEGR1 | T | 0.60 | -0.029 | 0.030 | 0.332 | -0.034 | 0.018 | 0.064 | -0.033 | 0.021 | 0.037 | 0.05 | 0.89 |
| rs10913469 | 1 | 176180142 | SEC16B, RASAL2 | T | 0.80 | 0.007 | 0.037 | 0.839 | 0.061 | 0.021 | 3.44×10-3 | 0.048 | 0.025 | 0.010 | 0.07 | 0.20 |
| rs2867125 | 2 | 612827 | TMEM18 | G | 0.83 | -0.137 | 0.039 | 4.98×10-4 | -0.046 | 0.023 | 0.040 | -0.068 | 0.027 | 5.91×10-4 | 0.13 | 0.04 |
| rs6548238 | 2 | 624905 | TMEM18 | C | 0.84 | -0.136 | 0.041 | 8.40×10-4 | -0.042 | 0.024 | 0.075 | -0.065 | 0.028 | 1.38×10-3 | 0.11 | 0.05 |
| rs7561317 | 2 | 634953 | TMEM18 | A | 0.84 | -0.132 | 0.040 | 8.60×10-4 | -0.048 | 0.023 | 0.033 | -0.069 | 0.027 | 3.83×10-4 | 0.13 | 0.07 |
| rs7647305 | 3 | 187316984 | SFRS10, ETV5, DGKG | C | 0.78 | -0.009 | 0.036 | 0.802 | -0.045 | 0.021 | 0.030 | -0.036 | 0.025 | 0.051 | 0.04 | 0.39 |
| rs10938397 | 4 | 44877284 | GNPDA2 | A | 0.55 | 0.094 | 0.030 | 1.70×10-3 | 0.050 | 0.017 | 4.30×10-3 | 0.061 | 0.020 | 8.13×10-5 | 0.18 | 0.99 |
| rs925946 | 11 | 27623778 | LGR4, LIN7C, BDNF | G | 0.68 | 0.060 | 0.031 | 0.053 | 0.022 | 0.018 | 0.231 | 0.031 | 0.021 | 0.050 | 0.04 | 0.29 |
| rs10838738 | 11 | 47619625 | MTCH2 | A | 0.64 | -0.007 | 0.031 | 0.812 | 0.020 | 0.018 | 0.263 | 0.013 | 0.021 | 0.408 | 0.01 | 0.45 |
| rs7138803 | 12 | 48533735 | BCDIN3D, FAIM2 | G | 0.62 | 0.077 | 0.030 | 0.012 | 0.015 | 0.018 | 0.412 | 0.030 | 0.021 | 0.054 | 0.04 | 0.08 |
| rs4788102 | 16 | 28780899 | SH2B1, ATP2A1 | G | 0.63 | 0.071 | 0.031 | 0.023 | 0.016 | 0.017 | 0.343 | 0.029 | 0.020 | 0.056 | 0.04 | 0.12 |
| rs7498665 | 16 | 28790742 | SH2B1 | A | 0.56 | 0.069 | 0.031 | 0.027 | 0.017 | 0.022 | 0.437 | 0.030 | 0.024 | 0.145 | 0.04 | 0.17 |
| rs9939609 | 16 | 52378028 | FTO | T | 0.59 | 0.087 | 0.031 | 4.60×10-3 | 0.052 | 0.017 | 2.60×10-3 | 0.061 | 0.020 | 8.63×10-5 | 0.18 | 0.99 |
| rs17782313 | 18 | 56002077 | MC4R | T | 0.76 | 0.108 | 0.036 | 2.50×10-3 | 0.049 | 0.020 | 0.014 | 0.063 | 0.024 | 2.83×10-4 | 0.15 | 0.15 |
| rs12970134 | 18 | 56035730 | MC4R | G | 0.74 | 0.097 | 0.034 | 4.11×10-3 | 0.063 | 0.019 | 8.21×10-4 | 0.071 | 0.023 | 2.36×10-5 | 0.20 | 0.38 |
| rs11084753 | 19 | 39013977 | KCTD15 | G | 0.67 | -0.012 | 0.031 | 0.710 | -0.015 | 0.018 | 0.400 | -0.014 | 0.021 | 0.371 | 0.01 | 0.54 |
| rs29941 | 19 | 39001372 | CHST8, KCTD15 | C | 0.68 | -0.017 | 0.032 | 0.599 | -0.011 | 0.018 | 0.525 | -0.012 | 0.021 | 0.427 | 0.01 | 0.87 |
Note: SNPs are based on those that reached p < 10-7 in Frayling et al. (2007); Loos et al. (2008); Thorleifsson et al. (2009) or Willer et al. (2009). Positions are based on NCBI build 126. Genes, allele and frequency are those given in the original studies. SNPs in italics indicate those that were not directly genotyped as part of this study, and were imputed instead.