. Author manuscript; available in PMC: 2012 Dec 15.

Published in final edited form as: Bioorg Med Chem. 2011 Oct 19;19(24):7570–7581. doi: 10.1016/j.bmc.2011.10.034

Table 2.

Activity of Schweinfurthin Analogues in the NCI 60 Cell Line Screen.²⁷

graphic file with name nihms-337135-t0002.jpg

Entry	Schweinfurthin	R =	R' =	Mean GI₅₀ (μM)	Differential (log units)	SF-295 GI₅₀ (μM)	A-549 GI₅₀ (μM)
1	51 ^a	H	H	10.15	1.56	1.66	13.2
2	53 ^a	F	H	6.23	1.40	5.01	2.14
3	54 ^a	SCH₃	H	7.95	1.58	3.80	6.03
4	56 ^b	OH	H	0.47	2.84	0.022	0.72
5	57 ^a	OCH₃	H	1.67	1.58	0.19	2.45
6	58 ^b	CH₂OH	MOM	1.66	2.56	0.15	1.41
7	60 ^a	CHO	MOM	6.30	2.46	1.20	7.8

Duplicate wells were run for each of these compounds in one assay.

Duplicate wells were run for each of these compounds in each of two independent assays and the average value is given in this table.