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. Author manuscript; available in PMC: 2011 Dec 6.
Published in final edited form as: Biochemistry. 2008 Apr 29;47(20):5608–5615. doi: 10.1021/bi800180g

Figure 4.

Figure 4

Figure 4

Active sites of the (A) Enzyme-Product and (B) Enzyme-Inhibitor complexes, shown in similar orientations. Nearby protein residues are shown as color-coded stick figures and ligand atoms as color-coded ball-and-stick figures (C: green, N: blue; O: red) with iron (M: orange) and water molecules (red) as spheres. Nw represents nucleophilic water, while W1-W3 represent structural waters stabilizing product binding.