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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Future Med Chem. 2011 Nov;3(15):1909–1934. doi: 10.4155/fmc.11.136

Table 4.

Known anti-inflammatory drugs and/or inhibitors of leukotrienes biosynthesis.

Number Compound Structure IC50 (μM) Ref.
10 Sulindac sulfide graphic file with name nihms338344t10.jpg 80 [26]
11 NS-398 graphic file with name nihms338344t11.jpg 20 [26]
12 Celecoxib graphic file with name nihms338344t12.jpg 22 [74]
13 Dimethylcelecoxib graphic file with name nihms338344t13.jpg 16 [74]
14 MK-886 graphic file with name nihms338344t14.jpg 1.6 [76]
15 Licofelone (ML3000) graphic file with name nihms338344t15.jpg 6 [80]

Determined by cell-free mPGES-1 activity assays.