Skip to main content
. Author manuscript; available in PMC: 2011 Dec 6.
Published in final edited form as: J Immunol. 2010 Jun 30;185(3):1419–1428. doi: 10.4049/jimmunol.1001140

Figure 6. MHC I is required for the sensitization of P14 CD8 T cells after poly(I:C) treatment.

Figure 6

P14 transgenic CD8 T cells were adoptively transferred into naïve WT or β2m KO congenic recipients followed by inoculation with 200 µg poly(I:C) i.p. At days 0 (untreated) and 1 post poly(I:C), splenocytes were stimulated with GP33–41 peptide + exogenous WT splenocytes ex vivo. A, P14 CD8 T cells were gated and intracellular accumulation of IFN-γ and TNF was assessed. B, The frequency of IFN-γ producing P14 cells was graphed (n=4/group). C, Functional IFN production was graphed. Data are representative of 4 independent experiments. **p<0.005