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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Biomaterials. 2011 Nov 5;33(4):1154–1161. doi: 10.1016/j.biomaterials.2011.10.033

Figure 2. Physicochemical characterization of freshly prepared and PUR-released si-NPs.

Figure 2

A) Dynamic light scattering demonstrated that si-NP diameter was around 40-nm at N/P ratios of 2 or greater, and at N/P = 1, the charge neutrality caused the NPs to be less stable and larger. This is further represented by the ζ–potential, which was slightly negative at N/P of 1, 8.3 mV at N/P of 2, and approximately 20 mV at all N/P of 4 or greater. B) The TEM image confirmed the micellar architecture and size of fresh si-NPs. Releasate si-NPs had a larger diameter of approximately 100 nm as shown both by DLS and TEM (B, bottom), and PUR-release si-NPs also had significantly reduced ζ–potential that was approximately charge neutral.