Figure 5. Release of siRNA and si-NPs from PUR scaffolds is diffusion controlled.

The Weibull empirical model equation best-fit was determined and is overlaid here for each data set. Naked siRNA is rapidly released with an initial burst of over 60% at 12 hours and is entirely released by 3 days. si-NPs have a slower rate of release with a burst release of less than 20% during the first 12 hours, followed by sustained release that approaches 80% by 21 days.