Table 1.
Composition and Physicochemical Properties of Lercanidipine hydrochloride Transdermal Patches
| Cod | Drug (mg) | Polymer | Weight (mg) | Thickness (µ) | Folding Endurance | Drug content (mg) |
|---|---|---|---|---|---|---|
| LRDP | ERL: HPMC | |||||
| A1 | 100 | 1.5:8.5 | 131.5±5.27 | 326±6.53 | 30.3±3.51 | 9.9±0.59 |
| A2 | 100 | 3:7 | 135.2±2.82 | 301±7.10 | 31.3±1.52 | 10.3±0.35 |
| A3 | 100 | 4:6 | 124.7±4.56 | 301±3.34 | 26.7±3.51 | 10.5±0.39 |
| A4 | 100 | 6:4 | 117.5±6.53 | 275±6.36 | 48.3±4.50 | 10.1±0.12 |
| A5 | 100 | 7:3 | 119.0±4.08 | 264±2.26 | 46.0±4.58 | 10.1±0.28 |
| A6 | 100 | 8.5:1.5 | 125.3±2.98 | 250±4.12 | 52.3±2.51 | 10.5±1.06 |
Note: Each patch (2.64 cm2) contained 10 mg of lercanidipine hydrochloride.
20% v/w of propylene glycol to the total polymer weight, incorporated as plasticizer.
8% v/w of d-limonene to the total polymer weight was used as penetration enhancer.
*
All values are expressed as mean±SD (n=3). ERL indicates Eudragit RL 100; HPMC, Hydroxypropyl Methyl Cellulose.