Table 3.
Estimates for the base, and final model and their Relative Standard Errors (RSE).
| Parameter | Base model MOF=2764.06 Units [Estimate (RSE%)] | relative final model MOF=2756.64 Units [Estimate (RSE%)] |
|---|---|---|
| Pharmacokinetic parameters | ||
| CL (l/hr) | 13.9 (7.0) | 13.40 (6.0) |
| Vd (l) | 41.0 (6.3) | 42.60 (7.2) |
| Interpatient variability | ||
| ωCL (%) | 32.5 (16) | 18.2 (18) |
| ωVd (%) | 20.0 (34) | 15.8 (15) |
| Residual variability | ||
| σ2 (%) | 39 | 32.1 |
| Covariates | ||
| CLθDIS | 0.14(7.2) | |
| VdθWT | 0.01(29) | |
θ: Estimate of covariates
ω: inter patient variability