Table 2.
Physicochemical properties of bilayered buccal tablets of sumatriptan succinate.
| Formulation code | Thickness (mm)* | Average weight of tablet (mg)±SD | Hardness(kg/cm2)±SD | Friability (%)* | Drug content (%)±SD | Surface pH* | Mucoadhesion time (h)±SD | Mucoadhesion strength (g)±SD |
|---|---|---|---|---|---|---|---|---|
| T1 | 3.12 | 151±1.43 | 5.2±0.14 | 0.463 | 98.74±1.74 | 6 | 12.0±1.25 | 21.0±1.32 |
| T2 | 3.12 | 151±1.18 | 5.2±0.17 | 0.453 | 97.85±1.35 | 6 | 10.0±0.50 | 19.0±0.20 |
| T3 | 3.11 | 150±1.72 | 5.4±0.18 | 0.411 | 98.00±2.20 | 7 | 09.0 ±1.30 | 17.5±0.97 |
| T4 | 3.05 | 151±1.26 | 5.4±0.23 | 0.372 | 98.86±3.40 | 6 | 12.0±1.35 | 20.4±0.60 |
| T5 | 3.05 | 149±1.56 | 5.4±0.11 | 0.449 | 99.01±2.01 | 6 | 10.0±0.30 | 17.5±1.45 |
| T6 | 3.04 | 150±1.21 | 5.6±0.16 | 0.403 | 98.79±1.92 | 7 | 09.0±0.40 | 15.6±1.90 |
Average of three determinations±SD
*
Average of three determinations