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Comparative pharmacokinetics parameters of sumatriptan succinate after oral and buccal administration in rabbits.
| Pharmacokinetic parameter | Pure drug | T1 |
|---|---|---|
| Ke (h−1) | 1.91 | 1.46 |
| Cmax (ng/ml) | 482.20±22.5 | 386.00±15.80 |
| Tmax (h) | 2.0 | 2.0 |
| AUC(0-24) (ng.h/ml) | 1199.64±150.60 | 1690.69±90.16 |
| AUC(0-8) (ng.h/ml) | 1200.90±150.60 | 1693.90±91.50 |
