Table 3.
Mean (±SD) pharmacokinetic parameters of Pd-Ia after intravenous administration
| Parameters | Control | Liver Cirrhosis |
|---|---|---|
| Initial body weight (g) | 190±13.4 | 189±12.5 |
| Final body weight (g) | 376±21.6 | 269±18.6** |
| AUC0-8 (min·µg·ml−1) | 68.4±13.9 | 111.8±29.7** |
| t1/2 (min) | 59.2±9.0 | 99.4±10.8** |
| CL (ml·min−1) | 15.5±2.3 | 8.3±1.8** |
| Vz(1) | 1.3±0.26 | 1.2±0.35 |
| 8 h Bile (% of dose) | 0.092±0.0033 | 0.126±0.0060** |
| Ae0–24 h (% of dose) | 0.114±0.0166 | 0.156±0.0252** |
| GI24 h (% of dose) | BDL | BDL |
AUC0-8: area under the analyte concentrations versus time curve from time 0 to infinity; t 1/2: terminal half-life; CL: total body clearance;
Vz: terminal volume of distribution; Ae0–24 h: urine samples at 24 hrs; GI24 h: gastrointestinal tract samples at 24 hrs
BDL: below the detection limit.
**P<0.01, significant difference compared to control.