Table 3.
Effect of bulk density and porosity on buoyancy of microballoons*.
| Drug: Polymer ratio | Bulk density (gm/cm3) | True density (gm/cm3) | Porosity (%) | Buoyancy (%) after 12 hrs | Inference (porosity (%) and% buoyancy) |
|---|---|---|---|---|---|
| 1:1 (MB1) | 0.6682±0.024 | 1.0169±0.0035 | 34.29±0.45 | 34.75±4.62 | Very low |
| 1:2 (MB2) | 0.5917±0.019 | 1.0102±0.0039 | 41.42±0.84 | 46.34±2.95 | Very low |
| 1:3 (MB3) | 0.5294±0.021 | 1.0016±0.0041 | 47.14±0.67 | 73.66±3.88 | Low |
| 1:4 (MB4)# | 0.4433±0.015 | 1.0012±0.0024 | 55.72±0.51 | 87.43±1.61 | High |
| 1:5 (MB5) | 0.4865±0.022 | 1.0018±0.0031 | 51.43±0.59 | 84.25±3.20 | Good |
*
All experiments were performed in triplicate (n=3),
#
optimized formulation.