Table.

Numerical Change of Gene^a and Centromere^b in Progressor, Non-progressor, and Normal Groups

	Progressor	Non-progressor	Normal		p
Case number	22	13	20	All groups	Progressor vs. Non-progressor	Progressor vs. Normal	Non-progressor vs. Normal
EGFR
No gain (%)	4 (18%)	11 (84%)	20 (100%)	< 0.0001	0.0006	< 0.0001	0.19
Low gain (%)	13 (59%)	1 (8%)	0
High gain (%)	5 (23%)	1 (8%)	0
CCND1
No gain (%)	1 (4%)	9 (70%)	20 (100%)	< 0.0001	0.0002	< 0.0001	0.03
Low gain (%)	7 (32%)	2 (15%)	0
High gain (%)	14 (64%)	2 (15%)	0
CEP7
Disomy (%)	7 (32%)	11 (84%)	20 (100%)	< 0.0001	0.009	< 0.0001	0.19
Trisomy (%)	12 (54%)	1 (8%)	0
Polysomy (%)	3 (14%)	1 (8%)	0
CEP11
Disomy (%)	5 (23%)	10 (77%)	20 (100%)	< 0.0001	0.007	< 0.0001	0.08
Trisomy (%)	9 (41%)	1 (8%)	0
Polysomy (%)	8 (36%)	2 (15%)	0

^aNo gain: gene signal ≤ 2 in > 90% of nuclei counted; low gain: gene signal ≥ 3 in ≥ 10% nuclei counted and gene signal ≥ 4 in < 10% nuclei counted; high gain: gene signal ≥ 4 in ≥ 10% of nuclei counted or Gene/CEP ratio ≥ 2 or tight clusters of gene signal ≥ 15 in ≥ 10% of nuclei counted.

^bDisomy: centermere signal ≤ 2 in > 90% of nuclei counted; Trisomy: centremere signal =3 in ≥ 10% and centremere signal ≥ 4 in < 10% nuclei counted; Polysomy: centremere signal ≥ 4 in ≥ 10% of nuclei counted.