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F o − F c electron-density map calculated before the AI-2 molecule was added to the LsrB atomic model. Contours within 2.8 Å of the AI-2 molecule are drawn at 3σ. Residues that form hydrogen bonds or van der Waals interactions with the AI-2 molecule are shown as ball-and-stick models. The hydrogen bond between the C2 hydroxyl group of the AI-2 ring and the carbonyl O atom of Pro218 is indicated.
