Table 1.
Completers (n = 389) | Dropouts (n = 48) | P-value | |
---|---|---|---|
Age, years | 61 ± 9 | 63 ± 9 | ns |
Gender, male:female | 205:184 | 26:22 | ns |
MRC | 3.6 ± 0.9 | 4.0 ± 1.0 | <0.05 |
BMI | 26.1 ± 5.6 | 25.6 ± 6.5 | ns |
HbCO | 1.6 ± 1.1 | 2.2 ± 1.6 | <0.05 |
BODE index | 4.6 ± 2.0 | 5.4 ± 2.1 | <0.05 |
% users of chronic oxygen | 17% | 42% | <0.001 |
# exacerbations | 5.2 ± 4.7 | 5.2 ± 3.2 | ns |
# hospitalization | 1.7 ± 2.4 | 2.3 ± 2.5 | ns |
Pulmonary function | |||
FEV1, L (% pred) | 1.08 ± 0.50 (41 ± 17) | 1.08 ± 0.50 (41 ± 17) | ns |
IVC, L (% pred) | 3.268 ± 0.97 (95 ± 19) | 3.11 ± 1.00 (91 ± 22) | ns |
Tiffeneau, % | 34 ± 12 | 32 ± 11 | ns |
TLC, L (% pred) | 7.02 ± 1.58 (122 ± 19) | 7.10 ± 1.65 (121 ± 21) | ns |
FRC, L. (% pred) | 4.79 ± 1.43 (156 ± 40) | 4.95 ± 1.42 (160 ± 43) | ns |
RV, L (% pred) | 3.77 ± 1.18 (178 ± 54) | 4.00 ± 1.28 (184 ± 62) | ns |
DLco, mmoL/min/kPa (% pred) | 3.76 ± 1.52 (45 ± 16) | 3.558 ± 1.60 (43 ± 18) | ns |
PaO2 at rest, kPa | 8.9 ± 1.2 | 8.5 ± 1.1 | ns |
PaCO2 at rest, kPa | 5.3 ± 0.8 | 5.6 ± 0.9 | <0.05 |
Exercise performance | |||
Wmax, Watt (% pred) | 44 ± 19 (33 ± 19) | 35 ± 24 (27 ± 14) | <0.05 |
6MWDT (% pred) | 366 ± 104 (57 ± 15) | 321 ± 102 (51 ± 16) | <0.01 |
CWR cycle test | 4.7 ± 3.2 | 4.3 ± 2.5 | ns |
Quality of life | |||
SGRQ total score | 66 ± 12 | 67 ± 12 | ns |
SF-36-PCS | 31 ± 79 | 31 ± 6 | ns |
SF-36-MCS | 42 ± 12 | 42 ± 12 | ns |
Notes: Data are presented as mean ± SD or n (%), unless otherwise indicated.
Abbreviations: MRC, Medical Research Council dyspnea scale; BMI, body mass index, BODE, body-mass index, airflow obstruction, dyspnea, and exercise capacity; FEV1, forced expiratory volume in 1 second; % pred, % predicted; L, liter; IVC, inspiratory vital capacity; TLC, total lung capacity; FRC, functional residual capacity; RV, residual volume; DLco, carbon monoxide transfer factor; PaO2, arterial oxygen tension; PaCO2, arterial carbon dioxide tension; Wmax, maximal power output on cycle ergometer; 6MWDT, 6 minute walking distance test; CWR, constant work rate; SGRQ, St George’s Respiratory Questionnaire; SF-36-PCS, Summary physical component score on the Medical Outcomes Study Short-Form Survey, version 2 (SF-36); SF-36-MCS, Summary mental component score on the SF-36; ns, non-significant.