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Comparison of Ki between crizotinib and AP26113 for wild-type ALK and ALK with LII96M gate-keeper mutation49
| Ki (nM) | ||
|---|---|---|
| ALK wild-type | ALK (L1196M) | |
| Crizotinib (PF02341066) | 0.69 | 8.2 |
| AP26113 | 0.09 | 0.08 |
Notes: Km of crizotinib and AP26113 using HotSpot kinase (Ki) determination studies by Reaction Biology Corporation (Malvern, PA).
Abbreviation: ALK, anaplastic lymphoma kinase.
