Table 3.
Baseline measures associated with improvement from CDR=0.5 at baseline to CDR=0 at followup. Logistic regression models based on participants with CDR=0.5 at baseline:
| Univariable model (adjusted for age, gender, and education) | Stepwise multivariable model* | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | OR | 95% CI for OR | P value | OR | 95% CI for OR | P value | ||
| Age 75–84† | -- | -- | -- | -- | 1.30 | 0.71 | 2.39 | 0.4017 |
| Age ≥85† | -- | -- | -- | -- | 0.91 | 0.39 | 2.15 | 0.8346 |
| Female gender | -- | -- | -- | -- | 1.30 | 0.76 | 2.22 | 0.3448 |
| Education ≥high school†† | -- | -- | -- | -- | 1.31 | 0.55 | 3.16 | 0.5424 |
| MMSE | 1.26 | 1.11 | 1.42 | 0.0003 | -- | -- | -- | -- |
| WRAT-3 Reading | 1.09 | 1.03 | 1.16 | 0.0049 | -- | -- | -- | -- |
| Digit Span Forward | 1.17 | 0.92 | 1.49 | 0.2081 | -- | -- | -- | -- |
| Category Fluency | 1.13 | 1.06 | 1.20 | <.0001 | 1.07 | 1.00 | 1.14 | 0.0434 |
| Letter Fluency | 1.06 | 1.00 | 1.12 | 0.0653 | -- | -- | -- | -- |
| Boston Naming Test | 1.10 | 1.04 | 1.16 | 0.0009 | -- | -- | -- | -- |
| I.U. Token Test | 1.50 | 1.23 | 1.83 | <.0001 | 1.34 | 1.08 | 1.65 | 0.0072 |
| WAIS-III Block Design | 1.07 | 1.03 | 1.10 | <.0001 | 1.03 | 0.99 | 1.06 | 0.1443 |
| WMS-R Visual Reproduction (Immediate) | 1.05 | 1.01 | 1.08 | 0.0166 | -- | -- | -- | -- |
| WMS-R Visual Reproduction (Delayed) | 1.05 | 1.02 | 1.07 | 0.0006 | -- | -- | -- | -- |
| WMS-R Logical Memory (Immediate) | 1.07 | 1.03 | 1.11 | 0.0009 | -- | -- | -- | -- |
| WMS-R Logical Memory (Delayed) | 1.05 | 1.02 | 1.09 | 0.0046 | -- | -- | -- | -- |
| OME sum of 3 trials | 1.19 | 1.11 | 1.28 | <.0001 | 1.13 | 1.05 | 1.23 | 0.0018 |
| SIT “Bag B” Recall | 1.37 | 1.17 | 1.60 | <.0001 | -- | -- | -- | -- |
| Clock Drawing | 1.19 | 1.01 | 1.40 | 0.0399 | -- | -- | -- | -- |
| Trail Making Test A | 0.99 | 0.98 | 1.00 | 0.1450 | -- | -- | -- | -- |
| Trail Making Test B | 0.99 | 0.99 | 1.00 | 0.0032 | -- | -- | -- | -- |
*
During the stepwise procedure, age, gender, and education were always included. Area under the ROC curve = 0.76 in final stepwise multivariable model.
†
The two older groups each compared to the 65–74 group (the reference group).
††
≥ High school education compared to < high school education (the reference group).