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. 2011 Dec 6;9(12):e1001212. doi: 10.1371/journal.pbio.1001212

Figure 7. Alterations in the metabolic parameters and in insulin signaling and sensitivity after treatment with antibiotics.

Figure 7

(A) Epididymal fat pad weight. (B) Visceral adipose tissue weight. (C) Glucose tolerance test. (D) Oxygen consumption. (E) Glucose uptake obtained by the euglycaemic hyperinsulinaemic clamp. (F) UCP-1 expression in the brown adipose tissue. (G) Serine phosphorylation of AKT after the treatment with AB. (H) Phosphorylation of JNK after the treatment with AB. (I) Zonula occludens (ZO)-1 expression in the ileum. Equal protein loading in the gel was confirmed by reblotting the membrane with an anti-β-actin antibody (lower panels). Data are presented as means ± S.E.M from six to eight mice per group, from experiments that were repeated at least three times. All evaluations were made with mice on standard chow. # p<0.05 between WT mice with or without insulin stimulus; * p<0.05 between WT and TLR2−/− mice with insulin stimulus; ** p<0.05 between TLR2−/− and TLR2−/− treated with AB, with insulin stimulus.