Table 2. Frequencies of CCL5 genotypes in the subcohort and hazard ratios (HR) and 95% confidence intervals (CI) for incident coronary events comparing CCL5 genotypes in the case-cohort dataset (MONICA/KORA Augsburg case-cohort study).

SNP	Allele*	n*	Weighted frequency (%)*	Model**	HR (95% CI) for genotype*
	1/2	11/12/22	11/12/22		11	12	22
rs2107538	C/T	1382/661/76	65.2/31.2/3.6	1	1 (ref)	1.06 (0.81–1.37)	0.98 (0.52–1.84)
				2	1 (ref)	1.04 (0.79–1.37)	1.13 (0.61–2.09)
rs2280788	C/G	2036/90/0	95.8/4.2/0	1	1 (ref)	0.55 (0.26–1.13)	N/A
				2	1 (ref)	0.57 (0.26–1.23)	N/A
rs2280789	T/C	1601/488/40	75.2/22.9/1.9	1	1 (ref)	1.01 (0.76–1.33)	0.80 (0.30–2.11)
				2	1 (ref)	0.99 (0.73–1.33)	0.96 (0.39–2.40)
rs4796120	A/G	1691/414/30	79.2/19.4/1.4	1	1 (ref)	1.02 (0.68–1.53)	0.96 (0.29–3.15)
				2	1 (ref)	0.95 (0.61–1.48)	0.96 (0.29–3.15)
rs3817655	T/A	1380/665/80	64.9/31.3/3.8	1	1 (ref)	1.06 (0.81–1.37)	0.83 (0.44–1.58)
				2	1 (ref)	1.04 (0.79–1.37)	0.81 (0.40–1.65)
rs1065341	A/G	1880/231/11	88.6/10.9/0.5	1	1 (ref)	1.00 (0.74–1.34)	1.08 (0.39–2.98)
				2	1 (ref)	0.98 (0.72–1.34)	1.28 (0.50–3.31)

*Allele 1 denotes the major allele, allele 2 denotes the minor allele. All alleles are shown in forward orientation according to dbSNP BUILD 133.

**Model 1: adjusted for age, sex and survey; Model 2: Model 1+BMI, systolic blood pressure, ratio of total cholesterol / HDL cholesterol, smoking status, alcohol intake, physical activity, history of diabetes.

N/A, not applicable (no homozygous carriers of the minor allele); ref, reference genotype.