Table 1. Plasmalogen levels in different tissues after control and AG-diet feeding.
Control diet | AG diet | ||||
Period | Sample | WT | KO | WT | KO |
2 months | RBC | 4.2±0.2 | 0.1±0.1 | 7.6±0.7 | 5.4±0.3 |
Liver | 0.5±0.1 | N.D. | 1.1±0.1 | 1.4±0.1 | |
Kidney | 3.5±0.2 | N.D. | 7.1±0.5 | 3.9±0.2 | |
Heart | 2.3±0.4 | N.D. | 9.8±1.6 | 9.6±1.1 | |
Lung | 8.1±0.9 | N.D. | 15.7±2.1 | 17.7±3.2 | |
Testis | 2.4±0.1 | N.D. | 3.4±0.2 | 2.1±0.5 | |
Eye | 4.0±0.1 | N.D. | 3.1±0.6 | 2.7±0.2 | |
Sciatic nerve | 26.7±7.1 | N.D. | 39±1.5 | 0.6±0.12 | |
Cerebrum | 13.7±2.8 | N.D. | 13.9±1.9 | 0.1±0.1 | |
Cerebellum | 14.5±1.0 | N.D. | 14.5 ±0.5 | 0.2±0.1 | |
Spinal cord | 21.3±6.1 | N.D. | 20.1±5.1 | N.D. | |
4 months | Cerebellum | N.P. | N.P. | 13.7±0.8 | 0.4±0.06 |
Spinal cord | N.P. | N.P. | 17.2±2.8 | 0.5±0.1 |
Plasmalogen levels are expressed as mean ± S.D of the percentages of dimethylacetal (DMA) derivatives of C18:0 to the corresponding saturated fatty acid.
Numbers of mice tested: on control diet WT mice (n = 4) and Pex7 KO mice (n = 3) and on AG diet for 2 months WT mice (n = 6) and Pex7 KO mice (n = 6); for 4 months WT (n = 3) and Pex7 KO mice (n = 3). RBC- red blood cells; AG- alkyl-glycerol diet; N.D.- not detected; N.P.- not performed.