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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Neurobiol Aging. 2011 Jul 30;33(8):1493–1506. doi: 10.1016/j.neurobiolaging.2011.06.008

Figure 4. APα showed no significant effect in 12-month-old nonTg and 3xTgAD mice.

Figure 4

(A) Learning curve of 12-month-old nonTg mice: NonTg mice showed low level of learning similar to 6 and 9-month-old nonTg mice. Treatment with APα did not alter the learning in nonTg mice significantly, although a positive trend was observed in the initial phase of training. (B) Learning curve of 12-month-old 3xTgAD mice: Vehicle-treated 3xTgAD mice showed almost no learning. APα did not affect the learning in these mice. (C) Memory test in 12-month-old mice: 3xTgAD mice exhibited a significant deficit in their memory compared to age-matched nonTg mice (P < 0.05). APα did not restore memory in both 3xTgAD and nonTg mice. (D) Cell survival analyses: 3xTgAD mice had a significantly reduced cell survival compared to nonTg mice (P < 0.0001). APα treatment showed no significant effect on cell survival in both 3xTgAD and nonTg mice. * P < 0.05; ** P < 0.0001 as compared to nonTg + vehicle group. Data are presented as average ± SEM (n ≥ 8).