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. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 29;879(32):3812–3817. doi: 10.1016/j.jchromb.2011.10.025

Table 3.

Matrix effect on ionization suppression of cediranib and ISTD.

a. Matrix effect on cediranib (Mean ± SD)
ng/mL Plasma Brain Homogenate
10 −39.1% ± 4.2% −35.6% ± 4.9%
100 −38.1% ± 2.0% −46.8% ± 0.8%
1000 −48.6% ± 1.3% −53.0% ± 1.4%
b. Matrix effect on AG1478 (Mean ± SD)
ng/mL Plasma Brain Homogenate
40 −52.6% ± 8.5% −44.8% ± 4.1%