. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Magn Reson Imaging. 2011 Oct 6;30(1):48–61. doi: 10.1016/j.mri.2011.07.007

Table 4.

Comparison of major findings in studies of resting-state DMN activity in aMCI groups compared to normal controls

	Present	Sorg2007	Bai2008	Qi2010
Subjects	aMCI	aMCI	aMCI	aMCI
Posterior Cingulate Cortex/Precuneus	−B	−L	−B	−B
Inferior Parietal Lobe	+L		+R	−R,+L
Medial Temporal Lobe(hippocampus, entorhinal cortex, perirhinal cortex, parahippocampal gyrus)	−L	^*
Fusiform Gyrus	−L		+R	−L
Lateral Prefrontal Cortex	−B	−R		+L
Medial Prefrontal Cortex	+B			+B
Middle Cingulate Cortex	+B
Medial Temporal Gyrus	−L			+L
Angular Gyrus	−R
Putamen			+B

“−”= decreased activities in aMCI; “+”= increased activities in aMCI; L=Left; R=Right; B=Bilateral.

^“*”

In addition to altered activity in DMN discovered by ICA, a ROI correlation analysis revealed that functional connectivity between both sides of hippocampus and left posterior cingulate cortex was absent in aMCI (Sorg et al. 2007).