Table 2.

Associations of ODC genotypes with risk of adenoma recurrence, Aspirin/Folate Polyp Prevention Study, 1994–2001

SNP	Positiona	Location	Call rate	PHWE	MAF	RR (95% CI)c	P	Qd
rs13000916	10490304	3’ flanking	0.995	0.09	0.449	0.89 (0.80–0.99)	0.031	0.07
rs11694911	10490649	3’flanking	0.991	0.96	0.106	1.29 (1.10–1.51)	0.002	0.027
rs2430419	10493239	3’flanking	1.000	0.59	0.247	1.09 (0.97–1.24)	0.15	0.27
rs2430420	10493677	3’flanking	1.000	0.86	0.324	1.17 (1.05–1.31)	0.005	0.027
rs10929669	10493883	3’flanking	0.997	0.61	0.115	1.22 (1.04–1.43)	0.017	0.054
rs28362434	10496095	3’flanking	1.000	0.82	0.183	0.94 (0.81–1.08)	0.36	0.52
rs818162	10496675	3’flanking	1.000	0.44	0.302	0.86 (0.76–0.97)	0.012	0.048
rs1049500	10498418	Exon 12b	1.000	0.57	0.041	1.38 (1.10–1.73)	0.005	0.027
rs28362416	10498720	Intron 11	0.996	0.10	0.067	0.85 (0.67–1.07)	0.18	0.29
rs7559979	10500130	Intron 8	0.985	0.61	0.347	1.05 (0.93–1.17)	0.44	0.59
rs28362380	10504231	Intron 1	0.999	0.83	0.103	1.04 (0.88–1.23)	0.67	0.77
rs2302615e	10505589	Intron 1	0.998	0.50	0.254	1.02 (0.90–1.15)	0.80
rs1728148	10508908	5’ flanking	0.999	0.79	0.451	0.92 (0.83–1.02)	0.12	0.24
rs885815	10509079	5’ flanking	0.992	0.32	0.214	0.96 (0.84–1.09)	0.51	0.63
rs2884211	10509623	5’ flanking	1.000	0.70	0.077	1.01 (0.83–1.23)	0.89	0.94
rs2357551	10509631	5’ flanking	1.000	0.73	0.342	1.13 (1.01–1.27)	0.029	0.07

Abbreviations: SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; RR, relative risk; CI, confidence interval.

^aLocation on chromosome 2p25 according to NCBI Human Genome Map Build 36.

^bThe substitution is synonymous.

^cPer allele relative risk and Wald test p-value using an additive genetic model adjusted for age and sex

^dFalse-discovery rate Q-values (27).

^ePreviously genotyped SNP, not included in multiple testing correction (n=765)(17).