Table 4.

Association of ODC genotypes with risk of adenoma recurrence stratified by aspirin treatment group, Aspirin/Folate Polyp Prevention Study, 1994–2001

	RR (95% CI)a
SNP	Placebo	81 mg/day Aspirin	325 mg/day Aspirin	Pint
rs13000916	0.89 (0.75–1.07)	0.94 (0.76–1.15)	0.84 (0.71–1.00)	0.76
rs11694911	1.40 (1.06–1.85)	1.24 (0.92–1.67)	1.31 (1.00–1.70)	0.82
rs2430419	0.91 (0.73–1.12)	1.13 (0.89–1.42)	1.27 (1.05–1.55)	0.08
rs2430420	0.99 (0.8201.20)	1.21 (0.98–1.49)	1.38 (1.15–1.66)	0.05
rs10929669	1.26 (0.94–1.69)	1.23 (0.92–1.66)	1.21 (0.94–1.56)	0.97
rs28362434	1.14 (0.91–1.44)	0.83 (0.62–1.11)	0.82 (0.65–1.04)	0.10
rs818162	0.94 (0.77–1.14)	0.77 (0.61–0.98)	0.84 (0.70–1.03)	0.45
rs1049500	1.42 (0.99–2.05)	1.53 (1.03–2.27)	1.16 (0.75–1.80)	0.63
rs28362416	0.63 (0.41–0.97)	0.79 (0.51–1.25)	1.19 (0.84–1.69)	0.08
rs7559979	1.01 (0.84–1.22)	1.15 (0.92–1.45)	0.98 (0.82–1.18)	0.50
rs28362380	0.75 (0.53–1.04)	1.39 (1.02–1.87)	1.03 (0.80–1.35)	0.03
rs2302615b	1.11 (0.91–1.36)	0.94 (0.73–1.21)	0.97 (0.79–1.19)	0.56
rs1728148	0.88 (0.73–1.06)	0.94 (0.76–1.15)	0.93 (0.78–1.10)	0.91
rs885815	1.13 (0.91–1.40)	0.86 (0.65–1.13)	0.86 (0.69–1.09)	0.19
rs2884211	0.95 (0.68–1.34)	1.06 (0.74–1.52)	1.06 (0.76–1.47)	0.89
rs2357551	1.05 (0.86–1.28)	1.15 (0.93–1.43)	1.22 (1.02–1.46)	0.56

Abbreviations: SNP, single nucleotide polymorphism; RR, relative risk; CI, confidence interval; P_int = P for interaction (between aspirin treatment and genotype, modeled additively).

^aPer allele relative risk using an additive genetic model adjusted for age and sex.

^bPreviously genotyped SNP (17)