Table 4.
Long term stability results for MPA (A), MPAG (B) and AcMPAG (C) at concentrations of 20μg/mL at baseline, 24 hours −80°C, 24 hour 4°C, 24 hours bench top, 1 week −80°C, 1 week 4°C, 1 week bench top, 1 month −80°C, and 1 month 4°C.
| Plasma | Urine | ||||||
|---|---|---|---|---|---|---|---|
| Timepoint | Temperature | Percent deviation from nominal ± Standard deviation | Percent deviation from nominal ± Standard deviation | ||||
| MPA | MPAG | AcMPAG | MPA | MPAG | AcMPAG | ||
| 24 Hours | Benchtop | 93.0 ± 2.6 | 105.3 ± 2.5 | 14.0 ± 0.5 | 104.0 ± 2.6 | 106.7 ± 3.2 | 62.3 ± 8.2 |
| 24 Hours | 4°C | 96.9 ± 2.8 | 105.7 ± 4.9 | 96.6 ± 5.0 | 107.0 ± 1.0 | 107.7± 0.6 | 91.2 ± 2.3 |
| 24 Hours | −80°C | 91.1 ± 2.3 | 102.5 ± 3.3 | 99.5 ± 7.8 | 106.7 ± 2.1 | 105.7 ± 1.5 | 92.3 ± 3.8 |
| 1Week | Benchtop | 90.7 ± 2.7 | 90.3 ± 13.0 | 0 ± 0.0 | 89.7 ± 2.5 | 25.4 ± 3.1 | 25.1 ± 0.9 |
| 1Week | 4°C | 87.1 ± 1.2 | 96.8 ± 2.3 | 36.1 ± 0.4 | 92.3 ± 3.5 | 28.9 ± 0.2 | 64.7 ± 1.4 |
| 1Week | −80°C | 87.9 ± 3.1 | 96.8 ± 9.8 | 101.6 ± 6.2 | 89.1 ± 2.2 | 27.9 ± 0.3 | 79.3 ± 1.4 |
| 1 Month | 4°C | 82.4 ± 8.1 | 87.1 ± 5.5 | 0 ± 0.0 | 87.8 ± 0.2 | 26.4 ± 1.0 | 4.0 ± 0.1 |
| 1 Month | −80°C | 97.8 ± 1.3 | 90.4 ± 1.6 | 86.8 ± 5.0 | 82.2 ± 0.3 | 26.4 ± 0.4 | 9.8 ± 0.1 |