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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Sep 1;4(12):2015–2026. doi: 10.1158/1940-6207.CAPR-11-0233

Figure 4.

Figure 4

A. Immunohistochemical staining for PCNA in intestinal tumors from APCMin/+ mice fed control diet or treated with licofelone.

B. Significant difference was observed in proliferative index between licofelone-treated and control group polyps.

C. TUNEL assay was performed for apoptotic cells in intestinal tumors from APCMin/+ mice fed control diet or treated with licofelone. A significant induction of apoptosis was observed in hyperplastic regions and polyps of treated mice compared with untreated mice.

D. A significant difference was observed in apoptotic index between licofelone-treated and control groups. Polyps from treated showed ~75% induction of apoptosis compared with polyps from control mice.