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. 2011 Nov 9;31(45):16049–16055. doi: 10.1523/JNEUROSCI.4064-11.2011

Figure 1.

Figure 1.

Molecular composition of the AIS. A, Na+ channel immunohistochemistry in neocortex reveals differential distribution of NaV1.2 and 1.6 isoforms to the proximal and distal AIS, respectively. Dashes outline somata. Image is a maximum-intensity projection of a 5-μm-thick confocal stack. Scale bar is 10 μm in A–C. B, Cultured rat hippocampal neuron triple labeled for MAP2, acetylated tubulin, and ankG to label the axon initial segment. C, Cultured hippocampal neuron expressing GFP, stained for the AIS-localized cell adhesion molecule neurofascin (NF)-186. Asterisk, NF-186 labeling of neighboring, non-GFP-positive neuron. D, A simplified, non-comprehensive diagram of some of the molecules found at the AIS. See text for abbreviations.