Fig. 5.

Histological features of FTLD-TDP types based on the classification of Mackenzie et al. a Features of FTLD-TDP type 1 (Sampathu, type 3) including short, thin neurites and pleomorphic neuronal cytoplasmic inclusions (NCI) with neuronal intranuclear inclusions (upper inset). b shows features of FTLD-TDP type 2 (Sampathu, type 1) including long, thick neurites in cortex (upper inset) as well as a Pick-body-like NCI in dentate fascia (lower inset). c Features of FTLD-TDP type 3 (Sampathu, type 2) including NCI and granular cytoplasmic staining (pre-inclusions—upper inset) with irregular granular NCI in dentate fascia (lower inset). c, d Features of FTLD-TDP type 4 including NCI, neurites and many neuronal intranuclear inclusions (lower insets). All with TDP-43 immunohistochemistry